Data for a randomized controlled trial of men receiving androgen suppression therapy for prostate cancer
School or Research Centre
Edith Cowan University Health and Wellness Institute
Edith Cowan University Research Online
Cancer Council of Western Australia
This dataset has been collected during a randomized controlled trial of 57 Western Australian men undergoing Androgen Suppression Therapy (AST) for prostate cancer. The participants were involved in a 12 week intervention study and undertook a regime of resistance training. The study examined the impact of the resistance training undergone in reducing the side effects of AST. The data that was collected includes physiological and physical measures (such as body mass, muscle strength, cardiorespiratory capacity, blood biomarkers) and questionnaires regarding a range of areas: quality of life, well being, length of time in therapy, types of treatment and the clinical characteristics of the subjects. SPSS was used to analyse the results.
The data has been gathered by Dr Daniel Galvao (ECU principal researcher) and Dennis Taaffe (University of Newcastle), Nigel Spry (University of Western Australia), David Joseph (University of Western Australia), Robert Newton (ECU). Funding for the project has been supplied by the Cancer Council of Western Australia.
Research Activity Title
Resistance and aerobic exercise in men receiving androgen suppression therapy for prostate cancer
Research Activity Description
In recent years there has been a substantial increase in the use of temporary androgen suppression treatment (AST) as an adjuvant management of prostate cancer. However, AST leads to a number of well established toxicity-related musculoskeletal deficits (eg, skeletal muscle loss, and strength), osteoporosis and skeletal fractures that can substantially reduce quality of life, physical function, and independence. In this research project 57 patients with prostate cancer, who were undergoing AST, participated in clinical trials. The participants were randomly assigned to a 12 week program of resistance and aerobic exercise. The conclusion was that a relatively brief exposure to exercise can significantly improved muscle mass, strength, physical function, and balance in hypogonadal men compared with normal care. The exercise regimen was well tolerated and could be recommended for patients undergoing AST as an effective countermeasure to these common treatment-related adverse effects.
Australian New Zealand Clinical Trial registry code: ACTRN12607000263493;
Start of data collection time period
End of data collection time period
Edith Cowan University owns the rights to this collection.
Contact Dr Daniel Galvao to determine access conditions.
Galvao, D. (2014). Data for a randomized controlled trial of men receiving androgen suppression therapy for prostate cancer. Edith Cowan University. Retrieved from http://ro.ecu.edu.au/datasets/5