Title

Distinct Effects of Testosterone on Plasma and Cerebrospinal Fluid Amyloid-beta Levels

Document Type

Journal Article

Publisher

IOS Press

Faculty

Computing, Health and Science

School

Exercise, Biomedical and Health Science

RAS ID

5921

Comments

This article was originally published as: Wahjoepramono, E. J., Wijaya, L. K., Taddei, K. , Martins, G. S., Howard, M. T., De Ruyck, K. , Bates, K. A., Dhaliwal, S., Verdile, G. , Carruthers, M., & Martins, R. N. (2008). Distinct Effects of Testosterone on Plasma and Cerebrospinal Fluid Amyloid-beta Levels. Journal of Alzheimer's Disease, 15(1), 129-137. Original article available here

Abstract

The effect of testosterone on the levels of the Alzheimer's disease amyloid-β peptide (Aβ) was investigated in guinea pigs. Castrated guinea pigs (GPX) were administered testosterone at two different dosages, following which plasma and cerebrospinal fluid (CSF) Aβ_{40} levels were measured. Plasma Aβ_{40} levels were reduced in GPX in the early stages of low-dose testosterone treatment, whereas CSF Aβ_{40} levels were only reduced by the time circulating testosterone had returned to untreated GPX levels. The supraphysiological testosterone dose did not reduce CSF Aβ_{40} levels significantly until circulating testosterone was back to uncastrated levels, whereas plasma Aβ_{40} levels significantly increased over time in these animals. These results indicate that the extent of testosterone-induced changes to Aβ_{40} levels and their response rates depend on both the tissue examined and testosterone dosage.

DOI

10.3233/JAD-2008-15111

 

Link to publisher version (DOI)

10.3233/JAD-2008-15111