Title

Infection and Alzheimer's Disease: The APOE epsilon 4 Connection and Lipid Metabolism

Document Type

Journal Article

Publisher

IOS Press

Faculty

Computing, Health and Science

School

Exercise, Biomedical and Health Science, Centre for Alzheimer's Disease

RAS ID

5924

Comments

This article was originally published as: Urosevic, N. , & Martins, R. N. (2008). Infection and Alzheimer's Disease: The APOE epsilon 4 Connection and Lipid Metabolism. Journal of Alzheimer's Disease, 13(4), 421-435. Original article available here

Abstract

Microorganisms, bacteria and viruses may infect and cause a range of acute and chronic diseases in humans dependent on the genetic background, age, sex, immune and health status of the host, as well as on the nature, virulence and dose of infectious agent. Late onset Alzheimer's disease (AD) is a progressive neurodegenerative illness of broad aetiology with a strong genetic component and a significant contribution of age, sex and life style factors. Both infectious diseases and AD are characterised by an increased production of an array of immune mediators, cytokines, chemokines and complement proteins by the host cells as well as by changes in the host lipid metabolism. In this review, we re-examine a dangerous liaison between several viral and bacterial infections and the most significant genetic factor for AD, APOE ε4, and the possible impact of this alliance on AD development. This connection was discussed in the broader context of lipid metabolism and in the light of different capacity of various infectious agents, their toxic lipophilic products and host lipoprotein particles for binding to cell receptor(s).