Title

B-Vitamins Reduce Plasma Levels of beta amyloid

Document Type

Journal Article

Publisher

Elsevier

Faculty

Computing, Health and Science

School

Exercise, Biomedical and Health Science, Centre for Alzheimer's Disease

RAS ID

6016

Comments

This article was originally published as: Flicker, L., Martins, R. N., Thomas, J., Acres, J., Taddei, K. , Vasikaran, S., Norman, P., Jamrozik, K., & Almeida, O. (2008). B-Vitamins reduce plasma levels of beta amyloid. Neurobiology of Aging, 29(2), 303-305. Original article available here

Abstract

Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1–40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD.

 

Link to publisher version (DOI)

10.1016/j.neurobiolaging.2006.10.007