Title

Molecular Markers of Circulating Melanoma Cells

Document Type

Journal Article

Publisher

Wiley-Blackwell Munksgaard

Faculty

Computing, Health and Science

School

Exercise, Biomedical and Health Science

RAS ID

5022

Comments

This article was originally published as: Medic, S. , Pearce, R. , Heenan, P., & Ziman, M. R. (2007). Molecular markers of circulating melanoma cells. Pigment Cell Research, 20(2), 80-91. Original article available here

Abstract

Of all skin cancers, cutaneous malignant melanoma (CMM) is the most aggressive and the life expectancy of patients with lymphatic or systemic metastases is dramatically reduced. Understandably therefore, scientists and clinicians have focused on improving diagnostic and prognostic techniques. Of these, perhaps the most promising are multimarker real-time RT-PCR and microarray for detection of circulating CMM cells in peripheral blood. While the optimal set of markers is still to be identified that can accurately assess disease severity and progression at all clinical stages of the disease, recent progress has been dramatic. Here we provide an exhaustive review of recent studies in which a variety of markers are assessed. Moreover, the efficacy of the markers relative to clinical stage is discussed in light of experimental findings. From these studies, it is apparent that researchers are now much closer to defining a set of markers of circulating cells that can be utilized in routine diagnostic tests.

DOI

10.1111/j.1600-0749.2006.00356.x

Access Rights

free_to_read

 

Link to publisher version (DOI)

10.1111/j.1600-0749.2006.00356.x