Title

Pax7 Expression in the Adult Rat Superior Colliculus Following Optic Nerve Injury

Document Type

Journal Article

Faculty

Computing, Health and Science

School

Exercise, Biomedical and Health Science

RAS ID

5121

Comments

This article was originally published as: Thomas, M., Barker, R., Beazley, L., & Ziman, M. R. (2007). Pax7 expression in the adult rat superior colliculus following optic nerve injury. Neuroreport, 18(2), 105-109. Original article available here

Abstract

The transcription factor Pax7 has been implicated in the normal development of the superior colliculus and continues to be expressed in the adult superior colliculus, where it is concentrated in the retino-recipient laminae. Here we assessed, immunohistochemically, Pax7 expression in the adult rat superior colliculus after unilateral intraorbital optic nerve transection. We show that after optic nerve transection, the number of Pax7-expressing cells increased to re-establish the developmental rostrallow-caudalhigh gradient and that these Pax7-expressing superior colliculus cells were neurons. These findings may have implications for the design of therapeutic interventions to restore functional connections in the adult visual pathway

DOI

10.1097/WNR.0b013e328010ff29

 

Link to publisher version (DOI)

10.1097/WNR.0b013e328010ff29