Pax7 Expression in the Adult Rat Superior Colliculus Following Optic Nerve Injury
Document Type
Journal Article
Faculty
Faculty of Computing, Health and Science
School
School of Exercise, Biomedical and Health Science
RAS ID
5121
Abstract
The transcription factor Pax7 has been implicated in the normal development of the superior colliculus and continues to be expressed in the adult superior colliculus, where it is concentrated in the retino-recipient laminae. Here we assessed, immunohistochemically, Pax7 expression in the adult rat superior colliculus after unilateral intraorbital optic nerve transection. We show that after optic nerve transection, the number of Pax7-expressing cells increased to re-establish the developmental rostrallow-caudalhigh gradient and that these Pax7-expressing superior colliculus cells were neurons. These findings may have implications for the design of therapeutic interventions to restore functional connections in the adult visual pathway
DOI
10.1097/WNR.0b013e328010ff29
Comments
Thomas, M., Barker, R., Beazley, L., & Ziman, M. R. (2007). Pax7 expression in the adult rat superior colliculus following optic nerve injury. Neuroreport, 18(2), 105-109. Available here