Title

Endogamy, consanguinity and community genetics

Document Type

Journal Article

Publisher

Springer India

Faculty

Computing, Health and Science

School

Biomedical and Sports Science

RAS ID

253

Comments

Originally published as: Bittles, A. H. (2002). Endogamy, consanguinity and community genetics. Journal of genetics, 81(3), 91-98. Original article available here

Abstract

The population of India is composed of many thousands of subpopulations, divided by geography, language, religion and caste or biraderi (patrilineage) boundaries, with endogamous marriage the norm. The net effect has been the creation of multiple genetic isolates with individual mutation profiles, but to date the clinical consequences of this highly complex differentiation have been largely ignored. In contrast, the topic of consanguinity continues to attract attention among medical and population geneticists, clinicians and social scientists. The significant progress made in India in improving childhood nutritional status and combating infectious disease means that genetic disorders have assumed ever increasing importance. In populations where consanguineous marriage is widely practised, recessive genetic disorders will continue to gain greater prominence in the overall spectrum of ill health. At the same time this increase will in part be negated by urbanization and the move to smaller family sizes, which predictably will result in a decline in the prevalence of consanguineous unions. Developing an understanding of these changes will require a wide-ranging and multidisciplinary investigative approach for which community genetics is ideally suited.

DOI

10.1007/BF02715905

 
COinS
 

Link to publisher version (DOI)

10.1007/BF02715905