Cell-based therapies for disorders of the CNS
Informa UK Ltd
Computing, Health and Science
School of Exercise, Biomedical and Health Science
There are few effective pharmacological-based treatments for acute neurological trauma or chronic neurodegenerative diseases. This has created a demand for innovative therapeutic approaches including gene therapy, deep brain stimulation and cell-based therapies. This review, briefly updates the progress made in recent clinical trials of neurotransplantation in Parkinson's and Huntington's disease, discusses challenges that still have to be overcome, and reviews the progress in meeting these challenges. The main focus of this review, however, will be on recent advances in using endogenous neural precursor cells (NPCs) to promote brain repair. The physiological role of NPCs, their response to various types of injury and other endogenous and exogenous factors will be discussed. Finally, their therapeutic potential and relevance to human disease will be considered.