Frontotemporale Lobardegenerationen, Teil 2: Bildgebung, Neuropathologie und Genetik
Georg Thieme Verlag
Health and Science
Exercise, Biomedical and Health Science, Centre for Alzheimer's Disease
Frontotemporal Lobar Degeneration (FTLD) is clinically heterogeneous, less common than Alzheimer's disease (AD), and - if at all - usually diagnosed in the presenium. The most common form, frontotemporal dementia (FTD) is characterized by changes in behaviour and personality, the less common progressive aphasia (PA) by a non-fluent aphasia and semantic dementia (SD) primarily by a loss of vocabulary and concepts. The diagnosis can be very difficult to make and therefore usually made only several years after the occurrence of the first ambiguous symptoms. The diagnosis relies on clinical criteria, including a neuropsychological collection of executive and language skills. Current therapeutic interventions aim at treating the symptomology, as no cure currently exists. Very important is the guidance and support of family members especially in patients with FTD, which are often exposed to an even greater burden than the relatives of patients with AD.