No Association of Lipase C Polymorphisms with Alzheimer's Disease

Document Type

Journal Article

Publisher

Elsevier

Faculty

Faculty of Health and Science

School

School of Exercise, Biomedical and Health Science / Centre of Excellence in Alzheimer’s Disease Research

RAS ID

7636

Comments

Laws, S. , Eckart, K., Friedrich, P., Eisele, T., Kurz, A., Forstl, H., & Riemenschneider, M. (2009). No association of Lipase C Polymorphisms with Alzheimer's disease. Neurobiology of Aging, n/a(n/a), n/a. Available here

Abstract

Hepatic lipase, also known as hepatic triglyceride lipase (LIPC), much like the major genetic risk factor for Alzheimer’s disease (AD), apolipoprotein E (APOE), is associated with altered lipid metabolism. As such this link makes LIPC a potential functional candidate for AD risk. Previously, three single nucleotide polymorphisms (SNPs) have been investigated in AD with a lack of association reported. To rule out a possible contribution of other variants in LIPC, located at 15q21-q23, we used a detailed fine mapping approach in a German case–control sample. Genotyping of 25 single nucleotide polymorphisms covering the complete LIPC gene and haplotypic analysis revealed no association with AD. Thus, we conclude that LIPC can be excluded as a major functional candidate gene conferring risk to AD.

DOI

10.1016/j.neurobiolaging.2008.12.004

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Link to publisher version (DOI)

10.1016/j.neurobiolaging.2008.12.004