Title

Yeast as a model for studying Alzheimer's disease

Document Type

Journal Article

Publisher

Oxford Academic

School

School of Excercise and health Science / Centre of Excellence for Alzheimer's Disease Research and Care

RAS ID

10723

Comments

Originally published as: Bharadwaj, P., Martins, R.N., & Macreadie, I. (2010). Yeast as a model for studying Alzheimer's disease. FEMS Yeast Research. 10(8), 961 - 969. Original article available here

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by acute cognitive decline. The AD brain is featured by extracellular senile amyloid plaques, intraneuronal neurofibrillary tangles and extensive neuronal cell loss in specific regions of the brain associated with memory. The exact mechanism of neuronal cell dysfunction leading to the memory loss in AD is poorly understood. A number of studies have indicated that yeast is a suitable model system to decipher the molecular mechanisms involved in a variety of neurodegenerative disorders caused by pathological protein misfolding and deposition. Here, the knowledge from various studies that have utilized a yeast model to study the mechanism of pathways involved in AD pathogenesis is summarized.

DOI

10.1111/j.1567-1364.2010.00658.x

 

Link to publisher version (DOI)

10.1111/j.1567-1364.2010.00658.x