Title

Maternal Consumption of Coffee and Tea During Pregnancy and Risk of Childhood ALL: Results from an Australian Case-Control Study

Document Type

Journal Article

Publisher

Springer

Faculty

Faculty of Computing, Health and Science

School

School of Exercise and Health Sciences / Child Health Promotion Research Centre

RAS ID

12479

Comments

This article was originally published as: Milne, E., Royle, J., Bennett, L., De Klerk, N., Bailey, H., Bower, C., Miller, M. R., Attia, J., Scott, R., Kirby, M., & Armstrong, B. (2011). Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: Results from an Australian case-control study. Cancer Causes and Control, 22(2), 207-218. Original article available here

Abstract

OBJECTIVES -To investigate whether maternal coffee and/or tea consumption during the last 6 months of pregnancy was associated with risk of childhood ALL. METHODS -Data on coffee and tea drinking during pregnancy from 337 case mothers and 697 control mothers were analyzed using unconditional multivariable logistic regression. A meta-analysis of our findings with those of previous studies was also conducted. RESULTS - There was little evidence of an overall association between maternal coffee consumption and risk of ALL: OR 0.89 (95% CI 0.61, 1.30), although there was some suggestion that higher levels of intake might increase the risk in children of non-smoking mothers: OR for 2+ cups/day = 1.44 (95% CI 0.85, 2.42); this was supported by our meta-analysis. Risk was also elevated among cases with chromosomal translocations. The overall OR for maternal tea consumption was 0.82 (95% CI 0.56, 1.18), although the OR for T-cell ALL was 0.21 (95% CI 0.08, 0.51). Among ALL cases with translocations, the ORs for tea consumption tended to be elevated: OR = 1.70 (95% CI 0.79–3.68) for 2+ cups/day. CONCLUSIONS -The observed increased risk associated with coffee and tea consumption may be confined to ALL with translocations. These associations should be explored further in large international consortia.

 

Link to publisher version (DOI)

10.1007/s10552-010-9688-1