Title

Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-β

Document Type

Journal Article

Publisher

IOS Press

Faculty

Faculty of Health, Engineering and Science

School

School of Medical Sciences/Centre of Excellence for Alzheimer's Disease Research and Care

RAS ID

16765

Comments

This article was originally published as: Lim, Y., Pietrzak, R., Ellis, K., Jaeger, J., Harrington, K., Ashwood , T., Szoeke, C., Martins, R. N., Bush, A., Masters, C., Rowe, C., Villemagne, V., Ames, D., Darby, D., & Maruff, P. (2013). Rapid decline in episodic memory in healthy older adults with high amyloid-β. Journal of Alzheimer's Disease, 33(3), 675-679. Original article available here

Abstract

High levels of amyloid-β (Aβ) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of Aβ-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate of Change Sub-Study, we compared rates of change in cognition over six months in healthy older adults with high and low levels of Aβ. High Aβ was associated with greater decline in episodic memory measures over 6 months in healthy older adults.

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