Rapid decline in episodic memory in healthy older adults with high amyloid-β
Authors
Yen Ying Lim
Robert H. Pietrzak
Kathryn A. Ellis
Judith Jaeger
Karra Harrington
Tim Ashwood
Cassandra Szoeke
Ralph N. Martins, Edith Cowan UniversityFollow
Ashley I. Bush
Colin L. Masters
Christopher C. Rowe
Victor L. Villemagne
David Ames
David Darby
Paul Maruff
Document Type
Journal Article
Publisher
IOS Press
Faculty
Faculty of Health, Engineering and Science
School
School of Medical Sciences / Centre of Excellence for Alzheimer's Disease Research and Care
RAS ID
16765
Abstract
High levels of amyloid-β (Aβ) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of Aβ-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate of Change Sub-Study, we compared rates of change in cognition over six months in healthy older adults with high and low levels of Aβ. High Aβ was associated with greater decline in episodic memory measures over 6 months in healthy older adults.
DOI
10.3233/JAD-2012-121516
Comments
Lim, Y., Pietrzak, R., Ellis, K., Jaeger, J., Harrington, K., Ashwood , T., Szoeke, C., Martins, R. N., Bush, A., Masters, C., Rowe, C., Villemagne, V., Ames, D., Darby, D., & Maruff, P. (2013). Rapid decline in episodic memory in healthy older adults with high amyloid-β. Journal of Alzheimer's Disease, 33(3), 675-679. Available here