Document Type

Journal Article

Publication Title

International Journal of Molecular Sciences

Volume

25

Issue

12

PubMed ID

38928043

Publisher

MDPI

School

Centre for Precision Health

RAS ID

71170

Funders

National Key Research and Development Program of China / Beijing Talents Project

Grant Number

2017YFE0118800, 2020A17

Comments

Wang, H., Liu, D., Meng, X., Sun, W., Li, C., Lu, H., ... & Wang, Y. (2024). Bidirectional two-sample mendelian randomization study of immunoglobulin G N-glycosylation and senescence-associated secretory phenotype. International Journal of Molecular Sciences, 25(12), 6337. https://doi.org/10.3390/ijms25126337

Abstract

Observational studies revealed changes in Immunoglobulin G (IgG) N-glycosylation during the aging process. However, it lacks causal insights and remains unclear in which direction causal relationships exist. The two-sample bidirectional Mendelian randomization (MR) design was adopted to explore causal associations between IgG N-glycans and the senescence-associated secretory phenotype (SASP). Inverse variance weighted (IVW) and Wald ratio methods were used as the main analyses, supplemented by sensitivity analyses. Forward MR analyses revealed causal associations between the glycan peak (GP) and SASP, including GP6 (odds ratio [OR] = 0.428, 95% confidence interval [CI] = 0.189–0.969) and GP17 (OR = 0.709, 95%CI = 0.504–0.995) with growth/differentiation factor 15 (GDF15), GP19 with an advanced glycosylation end-product-specific receptor (RAGE) (OR = 2.142, 95% CI = 1.384–3.316), and GP15 with matrix metalloproteinase 2 (MMP2) (OR = 1.136, 95% CI =1.008–1.282). The reverse MR indicated that genetic liability to RAGE was associated with increased levels of GP17 (OR = 1.125, 95% CI = 1.003–1.261) and GP24 (OR = 1.222, 95% CI = 1.046–1.428), while pulmonary and activation-regulated chemokines (PARC) exhibited causal associations with GP10 (OR = 1.269, 95% CI = 1.048–1.537) and GP15 (OR = 1.297, 95% CI = 1.072–1.570). The findings provided suggested evidence on the bidirectional causality between IgG N-glycans and SASP, which might reveal potential regulatory mechanisms.

DOI

10.3390/ijms25126337

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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