Title

Circulating Lipocalin 2 Levels Predict Fracture-Related Hospitalizations in Elderly Women: A Prospective Cohort Study

Authors

W.H. Lim

Document Type

Article

Publisher

John Wiley and Sons Inc.

School

School of Exercise and Health Sciences

RAS ID

20040

Comments

Originally published as: Lim, W.H., Wong, G., Lim, E.M., Byrnes, E., Zhu, K., Devine, A., Pavlos, N.J., Prince, R.L., Lewis, J.R. (2015). Circulating Lipocalin 2 Levels Predict Fracture-Related Hospitalizations in Elderly Women: A Prospective Cohort Study in Journal of Bone and Mineral Research, 30(11), 2078-2085. Available here.

Abstract

Lipocalin 2 (LCN2) or neutrophil gelatinase-associated lipocalin (NGAL) is expressed in a wide range of cells and pathological states. Mounting evidence suggests lipocalin 2 may be an important regulator of bone homeostasis. Recently it has been suggested LCN2 is a novel mechanoresponsive gene central to the pathological response to low mechanical force. We undertook a prospective study of 1009 elderly women over 70 years of age to study the association between circulating LCN2 and potential associated variables, including estimated glomerular filtration rate, physical activity, and baseline measures of hip bone density and heel bone quality. Osteoporotic fractures requiring hospitalizations were identified from the Western Australian Data Linkage System. Over 14.5 years, 272 (27%) of women sustained an osteoporotic fracture-related hospitalization; of these, 101 were hip fractures. Circulating LCN2 levels were correlated with body mass index and estimated glomerular filtration rate (r=0.249, p

DOI

10.1002/jbmr.2546