Title

Respiratory muscle training on pulmonary and swallowing function in patients with Huntington's disease: A pilot randomised controlled trial

Document Type

Journal Article

Publisher

SAGE Publications Inc.

School

School of Exercise and Health Sciences / Centre for Exercise and Sports Science Research

RAS ID

18420

Comments

The final version of this paper has been published as Respiratory muscle training on pulmonary and swallowing function in patients with Huntington's disease: A pilot randomised controlled trial. Clinical Rehabilitation, 29(10), October, 2015 by SAGE Publications Ltd, All rights reserved. Reyes, Alvaro, et al (2014). It is available here.

Abstract

Objective: To examine the effects of 4-month of respiratory muscle training on pulmonary and swallowing function, exercise capacity and dyspnoea in manifest patients with Huntington’s disease. Design: A pilot randomised controlled trial. Setting: Home based training program. Participants: Eighteen manifest Huntington’s disease patients with a positive genetic test and clinically verified disease expression, were randomly assigned to control group (n=9) and training group (n=9). Intervention: Both groups received home-based inspiratory (5 sets of 5 repetitions) and expiratory (5 sets of 5 repetitions) muscle training 6 times a week for 4 months. The control group used a fixed resistance of 9 centimeters of water, and the training group used a progressively increased resistance from 30% to 75% of each patient’s maximum respiratory pressure. Main measures: Spirometric indices, maximum inspiratory pressure, maximum expiratory pressure, six minutes walk test, dyspnoea, water-swallowing test and swallow quality of life questionnaire were assessed before, at 2 and 4 months after training. Results: The magnitude of increases in maximum inspiratory (d=2.9) and expiratory pressures (d=1.5), forced vital capacity (d=0.8), forced expiratory volume in 1 second (d=0.9) and peak expiratory flow (d=0.8) was substantially greater for the training group in comparison to the control group. Changes in swallowing function, dyspnoea and exercise capacity were small (d􀁤0.5) for both groups without substantial differences between groups. Conclusions: A home-based respiratory muscle training program appeared to be beneficial to improve pulmonary function in manifest Huntington

DOI

10.1177/0269215514564087