Title

Decreased platelet APP isoform ratios in autosomal dominant Alzheimer's desease : Baseline data from a DIAN chort subset

Document Type

Journal Article

Publisher

Bentham Science Publishers

Place of Publication

Bussum, Netherlands

Faculty

Faculty of Health, Engineering and Science

School

School of Medical and Health Sciences

RAS ID

20148

Comments

Originally published as: Chatterjee, P., Gupta, V. B., Fagan, A. M., Jasielec, M. S., Xiong, C., Sohrabi, H. R., ... Martins, R. N. (2015). Decreased platelet APP isoform ratios in autosomal dominant Alzheimer's desease : Baseline data from a DIAN chort subset. Current Alzheimer Research, 12(2), 157-164. Retrieved from http://europepmc.org/articles/pmc4383703?pdf=render. Original article available here

Abstract

Introduction

This study examines platelet amyloid precursor protein (APP) isoform ratios of 120KDa to 110KDa (APPr) between mutation carriers (MC) carrying a mutation for autosomal dominant Alzheimer’s disease (ADAD) and non-carriers (NC). Two previous studies reported no significant difference in APPr between ADAD MC and NC, which may have been due to the small sample size in both studies. The current study examines APPr in MC versus NC in a larger sample. In addition, it investigated whether APPr correlate with neuroimaging data, neuropsychological data and cerebrospinal fluid biomarkers in a cohort subset derived from the Dominantly Inherited Alzheimer Network (DIAN) study.

Methods

APPr were quantified by western blotting. Fifteen MC (symptomatic and asymptomatic) were compared against twelve NC using univariate general linear model. All participants underwent neuroimaging and neuropsychological testing which were correlated with APPr using Pearson’s correlation coefficient (r).

Results

APPr were lower in MC compared to NC (p=0.003) while Mini-Mental State Examination (MMSE) scores were not significantly different (p>0.1). Furthermore, APPr inversely correlated with amyloid imaging in the Caudate Nucleus (r=−0.505; p

Conclusion

APPr are lower in ADAD MC compared to NC, and inversely correlated with brain amyloid load prior to significant differences in cognitive health. However, the use of APPr as a biomarker needs to be explored further.

Access Rights

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