Title

Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

Document Type

Journal Article

Publisher

Japan Endocrine Society

Place of Publication

Kyoto, Japan

School

School of Medical and Health Sciences

RAS ID

19920

Comments

Originally published as: Yan, Y., We, L., Wang, S., Wang, W., Dong, J., & He, Y. (2015). Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population. Endocrine Journal, 62(10). 887-896. . Original article available here

Abstract

MicroRNA (miRNA) related genetic variation may change miRNA binding affinity and mRNA expression levels of the target genes, thus leading to altered metabolic parameters. This study explored the influence of let-7 related single nucleotide polymorphisms (SNPs) on individual susceptibility to metabolic syndrome (MetS) in a Chinese population. Seven SNPs located at the pri-let-7 gene region, pre-let-7 gene region or 3’-UTR of the KRAS gene were selected. The SNPs were genotyped in 503 MetS patients and 529 normal controls using the high-throughput Sequenom genotyping platform. Unconditional logistic regression analysis was utilized to estimate the association between these SNPs and the risk of MetS. There are three SNPs significantly associated with MetS. The A allele of rs17276588 was associated with an increased risk effect for MetS (Adjusted OR=1.75, 95%CI 1.37-2.25, P

DOI

10.1507/endocrj.EJ15-0236

Access Rights

Free_to_read

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