Title

The relationship between sleep quality and brain amyloid burden

Document Type

Journal Article

Publisher

Associated Professional Sleep Societies,LLC

Place of Publication

Westchester, USA

School

School of Medical and Health Sciences

RAS ID

21241

Comments

Originally published as: Brown, B. M., Rainey-Smith, S. R., Villemagne, V. L., Weinborn, M., Bucks, R. S., Sohrabi, H. R., ... Martins, R. N. (2016). The relationship between sleep quality and brain amyloid burden. Sleep, 39(5). 1063-1068. Original article available here

Abstract

To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E (APOE) ε4 allele on any associations found.This study is a cross-sectional analysis of 184 cognitively healthy men and women aged over 60 y. We measured sleep quality factors: specifically, sleep duration, latency (time taken to fall asleep), disturbances, efficiency, daytime dysfunction, and overall sleep quality, using the Pittsburgh Sleep Quality Index. All participants underwent Aβ positron emission tomography imaging for the quantification of brain Aβ burden and were APOE genotyped. Linear regression analyses were used to evaluate the relationship between sleep quality factors and brain Aβ burden, adjusting for age, body mass index, cardiovascular disease, and symptoms of depression, with APOE ε4 carriage entered as a moderator.Of the sleep factors, longer sleep latency was associated with higher levels of brain Aβ (B = 0.003 [standard error = 0.001], P = 0.02). APOE ε4 allele (carrier/noncarrier) did not moderate the relationship between sleep latency and brain Aβ burden.Our findings suggest a relationship between brain Aβ burden and sleep latency, independent of APOE ε4 genotype.

DOI

10.5665/sleep.5756

Access Rights

Not open access

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