Title

Mechanisms and mediators of the skeletal muscle repeated bout effect

Document Type

Journal Article

Publisher

American College of Sports Medicine

School

School of Medical and Health Sciences

RAS ID

22748

Comments

Originally published as: Hyldahl, R., Chen, T., Nosaka, K. (2017). Mechanisms and mediators of the skeletal muscle repeated bout effect. Exercise and Sport Sciences Reviews. 45(1), 24 - 33. Original article available here

Abstract

Skeletal muscle adapts to exercise-induced damage by orchestrating several but still poorly understood mechanisms that endow protection from subsequent damage. Known widely as the repeated bout effect, we propose that neural adaptations, alterations to muscle mechanical properties, structural remodeling of the extracellular matrix, and biochemical signaling work in concert to coordinate the protective adaptation.

DOI

10.1249/JES.0000000000000095

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