Increased carbohydrate intake is associated with poorer performance in verbal memory and attention in an APOE genotype-dependent manner

Document Type

Journal Article

Publication Title

Journal of Alzheimer's Disease

Publisher

IOS Press

School

School of Medical and Health Sciences / Center of Excellence for Alzheimer's Disease Research and Care

RAS ID

25003

Comments

Gardener, S. L., Rainey-Smith, S. R., Sohrabi, H. R., Weinborn, M., Verdile, G., Fernando, W. M. A. D., . . . Masters, C. L. (2017). Increased carbohydrate intake is associated with poorer performance in verbal memory and attention in an APOE genotype-dependent manner. Journal of Alzheimer's Disease, 58(1), 193-201. https://doi.org/10.3233/JAD-161158

Abstract

Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer’s disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of the apolipoprotein E (APOE) ɛ4 allele. We assessed the cross-sectional association between carbohydrate intake, cognitive performance, and cerebral amyloid-β (Aβ) load in CN older adults, genotyped for APOE ɛ4 allele carrier status. Greater carbohydrate intake was associated with poorer performance in verbal memory in APOE ɛ4 allele non-carriers, and poorer performance in attention in APOE ɛ4 allele carriers. There were no associations between carbohydrate intake and cerebral Aβ load. These results provide support to the idea that decreasing carbohydrate intake may offer neurocognitive benefits, with specific cognitive domains affected in an APOE genotype-dependent manner. These findings warrant further investigation utilizing a longitudinal study design.

DOI

10.3233/JAD-161158

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