Title

Prevalence and molecular epidemiology of Clostridium difficile infection in Indonesia

Document Type

Journal Article

Publisher

Elsevier Ltd

School

School of Medical and Health Sciences

RAS ID

24547

Comments

Originally published as: Collins, D. A., Gasem, M. H., Habibie, T. H., Arinton, I. G., Hendriyanto, P., Hartana, A. P., & Riley, T. V. (2017). Prevalence and molecular epidemiology of Clostridium difficile infection in Indonesia. New Microbes and New Infections, 18, pp. 34-37. Article available here.

Additional Information

Clostridium difficile has not been studied in detail in Asia, particularly Southeast Asia. We thus performed a prevalence study across four hospitals in Central Java province, Indonesia. Stool samples were collected from patients with diarrhoea and tested by enzyme immunoassay for glutamate dehydrogenase (GDH) and toxin A/B (C DIFF QUIK CHEK COMPLETE, TechLab). Specimens were cultured and molecular typing was performed. In total, 340 samples were tested, of which 70 (20.6%) were GDH positive, with toxin detected in 19 (5.6%). Toxigenic C. difficile was isolated from 37 specimens (10.9%), while a further 36 (10.6%) nontoxigenic isolates were identified. The most common strain was ribotype 017 (24.3% of 74 isolates), followed by nontoxigenic types QX 224 (9.5%), and QX 238 and QX 108 (both 8.1%). The high prevalence of C. difficile highlights a need for ongoing surveillance of C. difficile infection in Indonesia.

DOI

10.1016/j.nmni.2017.04.006

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