Effects of different exercise modalities on fatigue in prostate cancer patients undergoing androgen deprivation therapy: a year-long randomised controlled trial
Dennis Taaffe, Edith Cowan UniversityFollow
Robert Newton, Edith Cowan UniversityFollow
Nigel Spry, Edith Cowan UniversityFollow
David Joseph, Edith Cowan UniversityFollow
Suzanne K. Chambers, Edith Cowan UniversityFollow
Robert Gardiner, Edith Cowan UniversityFollow
Daniel A. Galvao, Edith Cowan UniversityFollow
School of Medical and Health Sciences
To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT.
Design, setting, and participants
Between 2009 and 2012, 163 prostate cancer patients aged 43–90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading + resistance training; ILRT; n = 58), the cardiovascular and muscular systems (aerobic + resistance training; ART; n = 54), or to usual care/delayed exercise (DEL; n = 51) for 12 mo across university-affiliated exercise clinics in Australia.
Supervised ILRT for 12 mo, supervised ART for 6 mo followed by a 6-mo home program, and DEL received a printed booklet on exercise information for 6 mo followed by 6-mo stationary cycling exercise.
Outcome measurements and statistical analysis
Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 36 and vitality using the Short Form-36. Analysis of variance was used to compare outcomes for groups at 6 mo and 12 mo.
Results and limitations
Fatigue was reduced (p = 0.005) in ILRT at 6 mo and 12 mo (∼5 points), and in ART (p = 0.005) and DEL (p = 0.022) at 12 mo. Similarly, vitality increased for all groups (p ≤ 0.001) at 12 mo (∼4 points). Those with the highest levels of fatigue and lowest vitality improved the most with exercise (ptrend < 0.001). A limitation was inclusion of mostly well-functioning individuals.
Different exercise modes have comparable effects on reducing fatigue and enhancing vitality during ADT. Patients with the highest levels of fatigue and lowest vitality had the greatest benefits.
We compared the effects of different exercise modes on fatigue in men on androgen deprivation therapy. All exercise programs reduced fatigue and enhanced vitality. We conclude that undertaking some form of exercise will help reduce fatigue, especially in those who are the most fatigued.