Document Type
Journal Article
Publication Title
Cancer Letters
Publisher
Elsevier Ireland Ltd
School
School of Medical and Health Sciences
RAS ID
24995
Funders
Western Australia Cancer Council grant (1100249) awarded to MM, MZ and EG. EG is also supported by a fellowship from the Cancer Research Trust
Abstract
Circulating tumour DNA (ctDNA) has emerged as a promising blood-based biomarker for monitoring disease status of patients with advanced cancers. In melanoma, ctDNA has been shown to have clinical value as an alternative tumour source for the detection clinically targetable mutations for the assessment of response to therapy. This review provides a critical summary of the evidence that gives credence to the utility of ctDNA as a biomarker for monitoring of disease status in advanced melanoma and the steps required for its implementation into clinical settings.
DOI
10.1016/j.canlet.2017.06.030
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Calapre, L., Warburton, L., Millward, M., Ziman, M., & Gray, E. S. (2017). Circulating tumour DNA (ctDNA) as a liquid biopsy for melanoma. Cancer Letters, 404, 62-69.
https://doi.org/10.1016/j.canlet.2017.06.030