Document Type

Journal Article

Publisher

Elsevier

School

School of Medical and Health Sciences

Comments

Originally published as: Marsavela, G., Aya-Bonilla, C. A., Warkiani, M. E., Gray, E. S., & Ziman, M. (2018). Melanoma circulating tumor cells: Benefits and challenges required for clinical application. Cancer letters. Original article available here

Abstract

The implementation of novel therapeutic interventions has improved the survival rates of melanoma patients with metastatic disease. Nonetheless, only 33% of treated cases exhibit long term responses. Circulating tumor cell (CTC) measurements are currently of clinical value in breast, prostate and colorectal cancers. However, the clinical utility of melanoma CTCs (MelCTCs) is still unclear due to challenges that appear intrinsic to MelCTCs (i.e. rarity, heterogeneity) and a lack of standardization in their isolation, across research laboratories. Here, we review the latest developments, pinpoint the challenges in MelCTC isolation and address their potential role in melanoma management.

DOI

10.1016/j.canlet.2018.03.013

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Share

 
COinS