Computerised dynamic posturography in premanifest and manifest individuals with Huntington's disease
Document Type
Journal Article
Publication Title
Scientific Reports
ISSN
2045-2322
Volume
8
Issue
1
First Page
14615
Last Page
14615
PubMed ID
30279429
Publisher
Nature
School
School of Medical and Health Sciences
RAS ID
27873
Abstract
Evidence from small-scale studies indicates that impairments in postural stability are an early and disabling feature of Huntington's disease (HD) and may be a useful clinical endpoint for disease modifying trials. Larger studies are needed to confirm these preliminary findings and the suitability of postural stability outcomes as clinical endpoints. Static and dynamic postural stability were evaluated in 54 premanifest HD, 36 manifest HD and 45 healthy individuals using the Sensory Organization Test (SOT) and Limits of Stability (LOS) test. Manifest HD displayed significantly lower scores on all SOT conditions and on the SOT composite score and had more falls than healthy and premanifest HD (p < 0.05). Premanifest and manifest HD demonstrated significantly lower endpoint excursion (p < 0.001), maximum excursion (p ≤ 0.001), and directional control (p ≤ 0.004) values than healthy individuals on the LOS test. Deficits in LOS were found to manifest on the left side of premanifest HD. Significant but low associations were observed between UHDRS-TMS, disease burden score, diagnostic confidence level, SOT conditions and SOT composite score. We confirm here that individuals with premanifest and manifest HD display significant impairments in static and dynamic postural stability. Dynamic posturography assessments should be considered as clinical endpoints for future disease modifying trials.
DOI
10.1038/s41598-018-32924-y
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Reyes, A., Salomonczyk, D., Teo, W. P., Medina, L. D., Bartlett, D., Pirogovsky-Turk, E., ... & Gilbert, P. E. (2018). Computerised dynamic posturography in premanifest and manifest individuals with Huntington’s Disease. Scientific reports, 8(1), 14615. Available here