Document Type

Journal Article

Publisher

Royal Society of Chemistry

Faculty

Faculty of Health, Engineering and Science

School

School of Medical Sciences/Centre of Excellence for Alzheimer's Disease Research and Care

RAS ID

18810

Comments

This article was originally published as: Rembach, A., Hare, D., Doecke, J., Burnham, S., Volitakis, I., Fowler, C., Cherny, R., McLean, C., Grimm, R., Martins, R. N., Ames, D., Masters, C., Bush, A., & Roberts, B. (2014). Decreased serum zinc is an effect of ageing and not Alzheimer's disease. Metallomics: integrated biometal science, 6(7), 1216-1219. Original article available here

Abstract

We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer’s disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.

DOI

10.1039/c4mt00060a

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