Title

Investigation of the role of amla in modulating cholesterol metabolism, and understanding its mechanism of action in reducing Alzheimer’s risk

Author Identifiers

Elham Teimouri
ORCID: 0000-0001-6923-8779

Date of Award

2018

Degree Type

Thesis

Degree Name

Doctor of Philosophy

School

School of Medical & Health Sciences

First Advisor

Professor Ralph Martins

Second Advisor

Dr Prashant R. Bharadwaj

Third Advisor

Dr Stephanie Rainey-Smith

Fourth Advisor

Dr Giuseppe Verdile

Field of Research Code

110999

Abstract

Alzheimer’s disease (AD) is a progressive degenerative disease of the brain and is associated with a number of cardiovascular disease risk factors. Dyslipidemia is a systemic metabolic change that occurs early in AD and recent studies have suggested using medicinal plant extracts as an effective treatment to slow the cognitive decline in AD. The main aim of this study is to investigate the clinical benefits of Amla, a bioactive Indian gooseberry, and to explore its potential cellular mechanisms that may underlie its effects. The findings presented in this thesis provide significant insight into our understanding of the lipid changes in blood and how they relate to AD pathogenesis and also into the possible molecular mechanisms underlying Amla’s beneficial effects.

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