Title

Redox Proteomics Identification of Oxidatively Modified Brain Proteins in Inherited Alzheimer's Disease: An Initial Assessment

Document Type

Journal Article

Publisher

IOS Press

Faculty

Faculty of Computing, Health and Science

School

School of Exercise, Biomedical and Health Science

RAS ID

4449

Comments

This article was originally published as: Butterfield, A. , Gnjec, A. , Poon, H., Castegna, A., Pierce, W., Klein, J., & Martins, R. N. (2006). Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: An initial assessment. Journal of Alzheimer's Disease, 10(4), 391-397. Original article available here

Abstract

Objective: To identify oxidatively modified proteins in brains of persons with inherited Alzheimer's disease. Methods: Redox proteomics was used to identify oxidatively modified brain proteins in persons with mutations in the genes for presenilin-1 (PS-1). Results: An initial redox proteomics assessment of oxidatively modified proteins from brains of individuals with PS-1 mutations was performed. These PS1 mutations, Q222H and M233T, are completely penetrant causing early-onset familial AD as previously reported in these Australian families. We show that oxidative modifications of ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), γ-enolase, actin, and dimethylarginine dimethylaminohydrolase 1 (DMDMAH-1) are present in the brain of familial AD subjects. Conclusions: These initial results suggest that oxidatively modified proteins are important common features in both familial and sporadic AD.

DOI

10.3233/JAD-2006-10407

 
COinS
 

Link to publisher version (DOI)

10.3233/JAD-2006-10407