Nestin Structure and Predicted Function in Cellular Cytoskeletal Organisation
Document Type
Journal Article
Publisher
Jimenez-Godoy
Faculty
Faculty of Computing, Health and Science
School
School of Exercise, Biomedical and Health Science
RAS ID
3582
Abstract
Nestin is an intermediate filament protein expressed in dividing cells during the early stages of development in the CNS, PNS and in myogenic and other tissues. Upon differentiation, nestin becomes downregulated and is replaced by tissue-specific intermediate filament proteins. Interestingly, nestin expression is reinduced in the adult during pathological situations, such as the formation of the glial scar after CNS injury and during regeneration of injured muscle tissue. Although it is utilised as a marker of proliferating and migrating cells very little is known about its functions or regulation. In depth studies on the distribution and expression of nestin in mitotically active cells indicate a complex role in regulation of the assembly and disassembly of intermediate filaments which together with other structural proteins, participate in remodeling of the cell. The role of nestin in dynamic cells, particularly structural organisation of the cell, appears strictly regulated by phosphorylation, especially its integration into heterogeneous intermediate filaments together with vimentin or a-internexin.
DOI
10.14670/HH-20.665
Comments
Michalczyk, K. , & Ziman, M. R. (2005). Nestin structure and predicted function in cellular cytoskeletal organisation. Histology and Histopathology, 20(1), 665-671. Available here