The bases of Western attitudes to consanguineous marriage
Faculty of Computing, Health and Science
School of Exercise, Biomedical and Health Science
There are frequent references to marriages between close biological relatives in the Bible, for example, the Patriarch Abraham and his wife Sarah (Genesis 20:12), and Amran and Jochebed, the parents of Aaron and Moses, who were related as nephew and aunt (Exodus 6:20). In both cases the parental couple would be expected to have inherited identical genes from a common ancestor(s) at 25% of all loci and so, on average, their offspring would have been homozygous at 12.5% of loci, equivalent to a coefficient of inbreeding (F) of 0.125.