No Association of Common VCP Variants With Sporadic Frontotemporal Dementia

Document Type

Journal Article

Publisher

Elsevier

Faculty

Faculty of Health and Science

School

School of Exercise, Biomedical and Health Science / Centre of Excellence in Alzheimer’s Disease Research

RAS ID

7634

Comments

Schumacher, A., Friedrich, P., Diehl-Schmid, J., Ibach, B., Schoepfer-Wendels, A., Mueller, J., Konta, L., Laws, S. , Kurz, A., Forstl, H., & Riemenschneider, M. (2009). No association of common VCP variants with sporadic frontotemporal Dementia. Neurobiology of Aging, 30(2), 333-5. Available here

Abstract

Mutations in the gene for valosin containing protein (VCP) cause autosomal dominant inclusion body myopathy associated with Paget disease and frontotemporal dementia (IBMPFD). To investigate the role of this novel gene in sporadic forms of frontotemporal dementia (FTD), we genotyped 27 single nucleotide polymorphisms covering the entire VCP genomic region in 198 patients with sporadic FTD and 184 matched controls from Germany. No significant association could be demonstrated. There is no evidence, that common variants in VCP confer a strong risk to the development of sporadic FTD.

DOI

10.1016/j.neurobiolaging.2007.05.023

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Link to publisher version (DOI)

10.1016/j.neurobiolaging.2007.05.023