Title

No association of vacuolar protein sorting 26 polymorphisms with alzheimer's disease

Document Type

Journal Article

Publisher

Elsevier

School

School of Biomedical and Sports Science

Comments

Riemenschneider, M., Schoepfer-Wendels, A., Friedrich, P., Konta, L., Laws, S. M., Mueller, J. C., ... & Förstl, H. (2007). No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease. Neurobiology of aging, 28(6), 883-884.https://doi.org/10.1016/j.neurobiolaging.2006.05.009

Abstract

Using a case-control sample we evaluated a possible involvement of the Vacuolar protein sorting 26 (VPS26) gene in the pathogenesis of AD. VPS26 located at 10q22.1 denotes a retromer subunit functionally involved in the cellular trafficking of Memapsin 2 (BACE). Genotyping of eight single nucleotide polymorphisms covering the complete VPS26 gene and haplotypic analysis revealed no association with AD. Thus, we conclude that VPS26 can be excluded as a major positional and functional candidate gene conferring risk to AD.

DOI

10.1016/j.neurobiolaging.2006.05.009

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Link to publisher version (DOI)

10.1016/j.neurobiolaging.2006.05.009