Author Identifier
Xiaojia Xu
https://orcid.org/0000-0003-2621-1618
Lois A. Balmer
https://orcid.org/0000-0001-5618-0555
Zhixian Chen
Document Type
Journal Article
Publication Title
Translational Metabolic Syndrome Research
ISSN
2588-9303
Volume
5
First Page
16
Last Page
23
Publisher
Elsevier
School
School of Medical and Health Sciences / Centre for Precision Health
RAS ID
44362
Funders
Guangdong Basic and Applied Basic Research Foundation (2021A1515010137)
Science and Technology Special Fund Project of Guangdong Province, grant number is 200113095894089
Grant for Key Disciplinary Project of Clinical Medical under the Guangdong High-level University Development Program
“Dengfeng Project” for the construction of high-level hospitals in Guangdong Province-the First Affiliated Hospital of Shantou University Medical College Supporting Funding (2019–70)
Abstract
Spondyloarthritis (SpA) is a group of chronic inflammatory arthritic diseases causing inflammatory back pain and stiffness, leading to irreversible damage of joint and spine, seriously affecting the quality of life. However, the exact pathogenesis of SpA is still unknown, although the blockers of tumor necrosis factor (TNF) are a major therapeutic advance. Of interest is the association between SpA and Immunoglobulin G (IgG) N-glycosylation. IgG N-glycosylation is a process of post-translational modification (PTM) that takes part in regulating anti- and pro-inflammatory effects. A relationship between IgG N-glycosylation and the development of inflammatory arthritic diseases exists, in addition this relationship often occurs before the onset of disease. There are studies reporting the association between IgG N-glycosylation and SpA, leading to a significant amount of data being generated. Analysis of this data in a rigorous form is greatly needed, hence this review will focus on identifying the relationships that exist between IgG N-glycosylation in inflammatory arthritis. More specifically, the modification to the structure of IgG N-glycosylation via TNF blockers as a treatment, the link between disease activity and IgG N-glycosylation, and the predictive capacity of IgG N-glycosylation in SpA. Investigation of IgG N-glycosylation has demonstrated that IgG N-galactosylation plays an important role in the development and prognosis of SpA. This association provides a novel pathway to further research to improve early diagnosis and possible biomarkers for treatment of patients with SpA.
DOI
10.1016/j.tmsr.2022.01.001
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Xu, X., Balmer, L., Chen, Z., Mahara, G., & Lin, L. (2022). The role of IgG N-galactosylation in spondyloarthritis. Translational Metabolic Syndrome Research, 5, 16-23. https://doi.org/10.1016/j.tmsr.2022.01.001