Title

Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease

Document Type

Journal Article

Publication Title

Alzheimer's and Dementia

Volume

18

Issue

10

First Page

1754

Last Page

1764

Publisher

Wiley

School

School of Medical and Health Sciences

RAS ID

42660

Funders

National Institute on Aging (NIA)

German Center for Neurodegenerative Diseases (DZNE)

Raul Carrea Institute for Neurological Research (FLENI)

Japan Agency for Medical Research and Development, AMED

NIHR UCL/UCLH Biomedical Research Centre

MRC Dementias Platform UK (MR/L023784/1 and MR/009076/1)

Comments

Buckles, V. D., Xiong, C., Bateman, R. J., Hassenstab, J., Allegri, R., Berman, S. B., ... & Dominantly Inherited Alzheimer's Network. (2022). Different rates of cognitive decline in autosomal dominant and late‐onset Alzheimer disease. Alzheimer's & Dementia, 18(10), 1754-1764. https://doi.org/10.1002/alz.12505

Abstract

As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and “sporadic” late-onset AD (LOAD) is critical to determine generalizability of findings between these cohorts. Cognitive trajectories of ADAD mutation carriers (MCs) and autopsy-confirmed LOAD individuals were compared to address this question. Longitudinal rates of change on cognitive measures were compared in ADAD MCs (n = 310) and autopsy-confirmed LOAD participants (n = 163) before and after symptom onset (estimated/observed). LOAD participants declined more rapidly in the presymptomatic (preclinical) period and performed more poorly at symptom onset than ADAD participants on a cognitive composite. After symptom onset, however, the younger ADAD MCs declined more rapidly. The similar but not identical cognitive trajectories (declining but at different rates) for ADAD and LOAD suggest common AD pathologies but with some differences.

DOI

10.1002/alz.12505

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