Myeloid sarcoma: A poorly recognised but important differential diagnosis of epithelioid angiosarcoma
Letter to the Editor
School of Medical and Health Sciences
To the Editor, Epithelioid angiosarcoma is a malignant neoplasm showing endothelial differentiation, distinguished from conventional angiosarcoma by prominent epithelioid cytomorphology. As a result, the differential diagnosis for pathologists is unique and focuses on tumours with predominant epithelioid features. This includes other vascular tumours such as epithelioid haemangioma and epithelioid haemangioendothelioma as well as non-vascular malignant neoplasms such as carcinoma and melanoma. Diagnosis in practice is usually uncomplicated as most examples demonstrate overtly malignant histological findings, allowing separation from benign or borderline vascular tumours. In addition, highly sensitive and specific immunohistochemical markers of endothelial differentiation such as CD31, CD34, ERG and FLI-1, facilitate their distinction from non-vascular mimics.