Association of c-reactive protein with cardiovascular outcomes: A mendelian randomization study in the Japanese population

Document Type

Journal Article

Publication Title

Biomedical and Environmental Sciences

Volume

35

Issue

2

First Page

126

Last Page

132

PubMed ID

35197177

Publisher

Chinese Center for Disease Control and Prevention

School

School of Medical and Health Sciences / Centre for Precision Health

RAS ID

51817

Funders

China-Australian Collaborative Grant [NSFC 81561128020-NHMRC APP1112767]

Comments

Cao, M. Y., Di, L. I. U., Zhang, X. Y., Tian, Q. Y., Zhang, Q., & Wang, Y. X. (2022). Association of C-reactive Protein with Cardiovascular Outcomes: A Mendelian Randomization Study in the Japanese Population. Biomedical and Environmental Sciences, 35 (2), 126-132. https://doi.org/10.3967/bes2022.017

Abstract

Objective: Traditional epidemiological studies have shown that C-reactive protein (CRP) is associated with the risk of cardiovascular diseases (CVDs). However, whether this association is causal remains unclear. Therefore, Mendelian randomization (MR) was used to explore the causal relationship of CRP with cardiovascular outcomes including ischemic stroke, atrial fibrillation, arrhythmia and congestive heart failure. Methods: We performed two-sample MR by using summary-level data obtained from Japanese Encyclopedia of Genetic association by Riken (JENGER), and we selected four single-nucleotide polymorphisms associated with CRP level as instrumental variables. MR estimates were calculated with the inverse-variance weighted (IVW), penalized weighted median and weighted median. MR-Egger regression was used to explore pleiotropy. Results: No significant causal association of genetically determined CRP level with ischemic stroke, atrial fibrillation or arrhythmia was found with all four MR methods (all Ps > 0.05). The IVW method indicated suggestive evidence of a causal association between CRP and congestive heart failure (OR: 1.337, 95% CI: 1.005–1.780, P = 0.046), whereas the other three methods did not. No clear pleiotropy or heterogeneity were observed. Conclusions: Suggestive evidence was found only in analysis of congestive heart failure; therefore, further studies are necessary. Furthermore, no causal association was found between CRP and the other three cardiovascular outcomes.

DOI

10.3967/bes2022.017

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free_to_read

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