Document Type

Journal Article

Publication Title

Metabolites

Volume

11

Issue

3

Publisher

MDPI

School

School of Medical and Health Sciences

RAS ID

35498

Funders

Australian Catholic University

Comments

Belhaj, M. R., Lawler, N. G., & Hoffman, N. J. (2021). Metabolomics and lipidomics: Expanding the molecular landscape of exercise biology. Metabolites, 11(3), article 151. https://doi.org/10.3390/metabo11030151

Abstract

Dynamic changes in circulating and tissue metabolites and lipids occur in response to exercise-induced cellular and whole-body energy demands to maintain metabolic homeostasis. The metabolome and lipidome in a given biological system provides a molecular snapshot of these rapid and complex metabolic perturbations. The application of metabolomics and lipidomics to map the metabolic responses to an acute bout of aerobic/endurance or resistance exercise has dramatically expanded over the past decade thanks to major analytical advancements, with most exercise-related studies to date focused on analyzing human biofluids and tissues. Experimental and analytical con-siderations, as well as complementary studies using animal model systems, are warranted to help overcome challenges associated with large human interindividual variability and decipher the breadth of molecular mechanisms underlying the metabolic health-promoting effects of exercise. In this review, we provide a guide for exercise researchers regarding analytical techniques and experimental workflows commonly used in metabolomics and lipidomics. Furthermore, we discuss advancements in human and mammalian exercise research utilizing metabolomic and lipidomic approaches in the last decade, as well as highlight key technical considerations and remaining knowledge gaps to continue expanding the molecular landscape of exercise biology.

DOI

10.3390/metabo11030151

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Research Themes

Health

Priority Areas

Exercise, nutrition, lifestyle and other interventions for optimal health across the lifespan

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