The Cholesterol-ceramide Connection As A Possible Link Between Diabetes And Alzheimer’s Disease
Omics Group Conference
Faculty of Health, Engineering and Science
School of Medical Sciences / Centre of Excellence for Alzheimer's Disease Research and Care
Molecular mechanisms involved with neuroendocrine diseases such as obesity and diabetes are closely linked to insulinresistance and require attention since metabolic dysfunction has also been associated with neurodegeneration. The global increase in these chronic diseases supports a role for lipids, such as ceramide and its metabolites in the pathogenesis ofthese diseases. The link between the ceramide and its pathogenesis of diabetes has been an important discovery that may assistwith the role of ceramide in the pathogenesis of Alzheimer’s disease (AD) also referred to as Type 3 diabetes. Lipids such as cholesterol and ceramide have been connected to processing of the amyloid precursor protein with generation or regulationof beta-amyloid production that is central to the amyloid hypothesis in AD. The cholesterol-ceramide connection has beenpreviously linked with aging and AD. Lipidomic analysis using mass spectrometry of fasting plasma from an ageing cohort (AIBL) that includes mild cognitively impaired individuals, cognitively healthy controls and AD patients at baseline havebeen provided in this study. The plasma lipid ceramide was elevated in AD patients and this study provides potential for early therapeutic targets that reduce ceramide levels to manage hypercholesterolemia and insulin resistance in both diabetes and AD.