Sex-specific association of BMI change with stroke in middle-aged and older adults with type 2 diabetes

Document Type

Journal Article

Publication Title

Nutrition, Metabolism and Cardiovascular Diseases

Volume

31

Issue

11

First Page

3095

Last Page

3102

PubMed ID

34511289

Publisher

Elsevier

School

School of Medical and Health Sciences

RAS ID

39646

Comments

Cui, C., Wu, Z., Shi, Y., Xu, Z., Zhao, B., Zhou, D., . . . Xu, X. (2021). Sex-specific association of BMI change with stroke in middle-aged and older adults with type 2 diabetes. Nutrition, Metabolism and Cardiovascular Diseases, 31(11), 3095-3102. https://doi.org/10.1016/j.numecd.2021.07.007

Abstract

Background and aims: We aimed to evaluate the association between BMI change and stroke in middle-aged and older adults with type 2 diabetes and identify sex differences. Methods and results: The China Health and Retirement Longitudinal Study is an ongoing national population-based cohort study. Participants aged 45 or above with type 2 diabetes were enrolled and followed for stroke incidence. BMI change was defined as BMI at 2013-BMI at 2011. Of 1774 participants (mean [SD] age in 2011, 60.23 [8.88] years), 795 (44.8 %) were men. A total of 112 incident stroke cases were confirmed up to 2018. The incidence rate of stroke was similar between men and women (6.79 % vs 5.92 %, P = 0.516). BMI increase was independently associated with an increased stroke risk (adjusted odds ratio, 1.15; 95 % CI, 1.05–1.31) in men, while this positive association was not significant in women (adjusted odds ratio, 1.12; 95 % CI, 0.98–1.29). In addition, the positive dose–response relationship between BMI increase and stroke was observed only in men. Conclusion: Among middle-aged and older adults with type 2 diabetes, there is a sex-specific association of BMI change with stroke. An increase in BMI could result in a higher risk of incident stroke in men.

DOI

10.1016/j.numecd.2021.07.007

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