Document Type

Book Chapter

Publisher

In-Tech

Place of Publication

United States

School

Centre of Excellence in Alzheimer’s Disease Research and Care/ School of Medical and Health Sciences

RAS ID

26266

Comments

Originally published as: Martins, I.,J. (2018). Caffeine with links to NAFLD and accelerated brain aging. In Baez, R., V. (Ed.), Non-Alcoholic Fatty Liver Disease: Molecular Bases, Prevention and Treatment (pp. 155-179). USA: In-Tech. Original article available here

Abstract

Nutritional diets are essential to prevent nonalcoholic fatty liver disease (NAFLD) in the global obesity and diabetes epidemic. The ingestion of palmitic acid-rich diets induces NAFLD in animal and human studies. The beneficial properties of olive oil (oleic acid) may be superseded by ingestion of palmitic acid-rich diets. Hepatic caffeine metabolism is regulated by palmitic and oleic acid with effects of these fats on amyloid beta metabolism. Healthy fats such as olive oil may facilitate rapid amyloid beta clearance in the periphery to maintain drug therapy in diabetes and various neurological diseases. Repression of the anti-aging gene sirtuin 1 (Sirt 1) prevents the beneficial properties of olive oil. Brain disorders induce NAFLD and supersede caffeine’s therapeutic effects in the prevention of NAFLD. Delayed hepatic caffeine metabolism in NAFLD and increased caffeine transport to the brain with aging-induced mitophagy in neurons with induction of type 3 diabetes and neurodegenerative disease.

DOI

10.5772/intechopen.70581

Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

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