Document Type

Journal Article

Publisher

Codon Publications

School

School of Medical and Health Sciences

RAS ID

26761

Comments

Originally published as: Shirolkar, G. D., Pasic, S., Gogoi-Tiwari, J., Bhat, M. K., Olynyk, J. K., Dharmarajan, A., & Tirnitz-Parker, J. E. (2018). Wnt/β-Catenin Signalling during Liver Metabolism, Chronic Liver Disease and Hepatocarcinogenesis. Journal of Renal and Hepatic Disorders, 2(1), 1-9. Original article available here

Abstract

Chronic liver diseases (CLDs) are increasing in prevalence and their end-stage complications, namely, cirrhosis, liver failure and hepatocellular carcinoma represent major global challenges. The most common initiators of progressive CLD are viral hepatitis and long-term alcohol abuse as well as steatosis and steatohepatitis. Irrespective of the underlying aetiology, a common feature of CLD is the formation of hepatic ductular reactions, involving the proliferation of liver progenitor cells (LPCs) and their sig­nalling to fibrosis-driving hepatic stellate cells. The Wnt/β-catenin pathway has been found to regulate development, stemness and differentiation, and alterations in its activity have been associated with tumour development. Recent data highlight the role of Wnt/β-catenin signalling in hepatic metabolism, steatosis and cancer, and suggest targeting of this pathway as a promising molecular strategy to potentially inhibit CLD progression and hepatocarcinogenesis.

DOI

10.15586/jrenhep.2018.29

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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