Title

Activity behaviours and physiological characteristics of women with advanced-stage Ovarian Cancer: a preliminary cross-sectional investigation.

Document Type

Journal Article

Publication Title

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

ISSN

1525-1438

Volume

28

Issue

3

First Page

604

Last Page

613

PubMed ID

29369120

Publisher

Blackwell Science

School

School of Medical and Health Sciences / Exercise Medicine Research Institute

RAS ID

26659

Comments

Originally published as : Schofield, C., Newton, R. U., Cohen, P. A., Galvão, D. A., McVeigh, J. A., Hart, N. H., ... & Peddle-McIntyre, C. J. (2018). Activity behaviors and physiological characteristics of women with advanced-stage ovarian cancer: a preliminary cross-sectional investigation. International Journal of Gynecological Cancer, 28(3), 604-613. Original article can be found here

Abstract

OBJECTIVES: Ovarian cancer (OC) survivors experience many disease and treatment adverse effects. However, the impact of OC and its treatment on objective activity behaviors and physiological status have not been examined. The purpose of this study was to compare objectively measured activity behaviors and physiological characteristics of advanced-stage OC survivors to age-matched controls.

METHODS: Twenty stage III-IV OC survivors and 20 controls completed assessments of activity behaviors (7-day accelerometry), physical function (400-meter walk as indicator of cardiorespiratory fitness, repeated chair rise, 6-meter walking tests), muscle strength (1-repetition maximum and handgrip), body composition (dual-energy x-ray absorptiometry), and musculoskeletal morphology (peripheral quantitative computed tomography).

RESULTS: Compared with controls, OC survivors spent more time/day in prolonged sedentary bouts (P = 0.039, r = 0.32), had lower cardiorespiratory fitness (P = 0.041, r = 0.33) and upper body strength (P = 0.023, r = 0.37), had higher areal bone mineral content (P = 0.047, r = 0.33) and volumetric trabecular density (P = 0.048, r = 0.31), but were not different in other measures of body composition nor in muscle morphology (P > 0.050). Only 20% (n = 4) of OC survivors accrued 150 minutes/week or greater moderate and vigorous physical activity (MVPA) time in 10-minute bouts or greater. Moderate and vigorous physical activity time/day in 10-minute bouts or greater was strongly associated with cardiorespiratory fitness (P = 0.001, ρ = -0.702) and lower extremity function (P = 0.019, ρ = -0.519) and moderately associated with muscle cross-sectional area (P = 0.035, ρ = 0.473).

CONCLUSIONS: Posttreatment OC survivors spent more time in prolonged sedentary bouts and had lower cardiorespiratory fitness and upper body strength compared with controls. Moderate and vigorous physical activity was associated with physical function and muscle cross-sectional area. Future studies should test the efficacy of exercise interventions to increase MVPA, reduce sedentary behavior, and increase cardiorespiratory fitness and muscle strength in OC survivors.

DOI

10.1097/IGC.0000000000001197

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