Alzheimer's Disease: Toward a quantitative biological approach in describing its natural history and underlying mechanisms

Authors

Colin Masters
Ben Gu
Simon Laws, Edith Cowan UniversityFollow
Yen Y. Lim
Blaine Roberts
Victor L. Villemagne
Konrad Beyreuther

Document Type

Book Chapter

Publication Title

The Molecular and Cellular Basis of Neurodegenerative Diseases

Publisher

Elsevier Inc

School

School of Medical and Health Sciences

RAS ID

27447

Comments

Masters, C. L., Gu, B., Laws, S., Lim, Y. Y., Roberts, B., Villemagne, V. L., & Beyreuther, K. (2018). Alzheimer’s Disease: Toward a quantitative biological approach in describing its natural history and underlying mechanisms. In M. S. Wolfe (Ed.), The Molecular and Cellular Basis of Neurodegenerative Diseases (pp. 57-79). Elsevier. https://doi.org/10.1016/B978-0-12-811304-2.00003-1

Abstract

Alzheimer’s disease remains a major therapeutic challenge despite a massive research effort over the past two decades. Applying quantitative mechanistic approaches to understanding the quantities and rates of Aβ amyloid production, accumulation and clearance may provide novel and more rigorous insights into developing rational therapeutic strategies.

DOI

10.1016/B978-0-12-811304-2.00003-1

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