Title

Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

Document Type

Journal Article

Publication Title

Alzheimer's & Dementia

Publisher

Elsevier Inc.

School

School of Medical and Health Sciences / Centre of Excellence for Alzheimer's Disease Research and Care

RAS ID

27381

Comments

Originally published as:

Müller, S., Preische, O., Sohrabi, H. R., Gräber, S., Jucker, M., Ringman, J. M., ... & Rossor, M. (2018). Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia, 14(11). 1427-1437.

Original article available here.

Abstract

Introduction

Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer's disease (AD).

Methods

A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross-sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations.

Results

Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD-like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers.

Discussion

These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.

DOI

10.1016/j.jalz.2018.06.3059

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