Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions

Document Type

Journal Article

Publication Title

The Journal of Physiology

ISSN

1469-7793

Volume

597

Issue

1

First Page

319

Last Page

332

PubMed ID

30328105

Publisher

Cambridge University Press

School

School of Medical and Health Sciences

RAS ID

29842

Comments

Kavanagh, J. J., McFarland, A. J., & Taylor, J. L. (2019). Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions. The Journal of Physiology, 597(1), 319-332.

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Abstract

KEY POINTS: Animal preparations have revealed that moderate synaptic release of serotonin (5-HT) onto motoneurones enhances motor activity via activation of 5-HT

ABSTRACT: Brief stimulation of the raphe-spinal pathway in the turtle spinal cord releases serotonin (5-HT) onto motoneurones to enhance excitability. However, intense release of 5-HT via prolonged stimulation results in 5-HT spillover to the motoneurone axon initial segment to activate inhibitory 5-HT

DOI

10.1113/JP277148

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