Title

Human versus non-human sex steroid use in hormone replacement therapies part 1: Preclinical data

Document Type

Journal Article

Publication Title

Molecular and Cellular Endocrinology

ISSN

1872-8057

Volume

480

First Page

12

Last Page

35

PubMed ID

30308266

Publisher

North Holland Publishing

School

School of Exercise, Biomedical and Health Sciences

RAS ID

31287

Comments

Atwood, C. S., & Ekstein, S. F. (2018). Human versus non-human sex steroid use in hormone replacement therapies part 1: Preclinical data. Molecular and Cellular Endocrinology 480, 12-35.

Available here.

Abstract

Prior to 2002, hormone replacement therapy (HRT) was considered to be an important component of postmenopausal healthcare. This was based on a plethora of basic, epidemiological and clinical studies demonstrating the health benefits of supplementation with human sex steroids. However, adverse findings from the Women's Health Initiative (WHI) studies that examined the 2 major forms of HRT in use in the US at that time - Premarin (conjugated equine estrogens; CEE) and Prempro (CEE + medroxyprogesterone acetate; MPA), cast a shadow over the use of any form of HRT. Here we review the biochemical and physiological differences between the non-human WHI study hormones - CEE and MPA, and their respective human counterparts 17β-estradiol (E

DOI

10.1016/j.mce.2018.10.003

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