Title

Human versus non-human sex steroid use in hormone replacement therapies part 1: Preclinical data

Document Type

Journal Article

Publication Title

Molecular and cellular endocrinology

ISSN

1872-8057

Volume

480

First Page

12

Last Page

35

PubMed ID

30308266

Publisher

North Holland Publishing

School

School of Exercise, Biomedical and Health Sciences

Comments

Originally published as:

Atwood, C. S., & Ekstein, S. F. (2018). Human versus non-human sex steroid use in hormone replacement therapies part 1: Preclinical data. Molecular and Cellular Endocrinology 480, 12-35.

Original article available here.

Abstract

Prior to 2002, hormone replacement therapy (HRT) was considered to be an important component of postmenopausal healthcare. This was based on a plethora of basic, epidemiological and clinical studies demonstrating the health benefits of supplementation with human sex steroids. However, adverse findings from the Women's Health Initiative (WHI) studies that examined the 2 major forms of HRT in use in the US at that time - Premarin (conjugated equine estrogens; CEE) and Prempro (CEE + medroxyprogesterone acetate; MPA), cast a shadow over the use of any form of HRT. Here we review the biochemical and physiological differences between the non-human WHI study hormones - CEE and MPA, and their respective human counterparts 17β-estradiol (E

DOI

10.1016/j.mce.2018.10.003

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