Title

Improved specificity with 68Ga PSMA PET/CT to detect clinically significant lesions “invisible” on multiparametric MRI of the prostate: a single institution comparative analysis with radical prostatectomy histology

Document Type

Journal Article

Publication Title

European Journal of Nuclear Medicine and Molecular Imaging

ISSN

1619-7089

Volume

46

Issue

1

First Page

20

Last Page

30

PubMed ID

30229528

Publisher

Springer-Verlag Berlin

School

School of Medical and Health Sciences

Comments

Originally published as: Donato, P., Roberts, M. J., Morton, A., Kyle, S., Coughlin, G., Esler, R., . . . Yaxley, J. (2019). Improved specificity with 68Ga PSMA PET/CT to detect clinically significant lesions “invisible” on multiparametric MRI of the prostate: A single institution comparative analysis with radical prostatectomy histology. European Journal of Nuclear Medicine and Molecular Imaging, 46(1), 20-30. Original Article available here

Abstract

PURPOSE: Positron emission tomography (PET) for prostate-specific membrane antigen (PSMA) represents a promising method for prostate cancer diagnosis and staging. Comparisons of PSMA-based tumour characterisation to multiparametric MRI (mpMRI) are limited, hence this study sought to compare the diagnostic accuracy of

METHODS: A retrospective cohort study of consecutive patients who underwent pre-operative mpMRI and

RESULTS: Fifty-eight patients (median age 65.5 years, median PSA 7.35 ng/mL) underwent RP, resulting in a high-risk cohort (≥pT3 69%). Sensitivities for identification of index lesion, bilateral and multifocal disease were 90%, 21%, 19% for mpMRI and 93%, 42%, 34% for

CONCLUSIONS:

DOI

10.1007/s00259-018-4160-7

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