Title

Autophagy promotes memory formation

Document Type

Journal Article

Publication Title

ACS Chemical Neuroscience

ISSN

1948-7193

Volume

10

Issue

8

First Page

3337

Last Page

3339

PubMed ID

31244056

Publisher

ACS Publications

School

The Centre of Excellence for Alzheimer’s Disease Research and Care / School of Medical and Health Sciences

Comments

Originally published as: Tripathi, T., Kalita, P., Martins, R., & Bharadwaj, P. (2019). Autophagy promotes memory formation. ACS Chemical Neuroscience, 10(8), 3337-3339. Original publication available here

Abstract

Autophagy is traditionally known to be a stress response and a quality control mechanism for protecting cells from injury and disease. In addition to its housekeeping functions, autophagy also has specialized functions including regulation of synaptic activity and neurotransmission. Decreased autophagy is commonly associated with aging; however, the functional importance of autophagy in regulating cognitive function and its decline during aging were previously not known. A recent study showed that the induction of hippocampal autophagy improves cognition by enhancing memory formation and reverses memory decline during aging. Here, we discuss the findings of that study and explore the scope of the physiological process of autophagy in the development of treatments for age-related cognitive decline and neurodegenerative diseases.

DOI

10.1021/acschemneuro.9b00317

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