Title

Influence of Ag alloying on the antibacterial properties, bio-corrosion resistance and biocompatibility of α-Nb5Si3 nanocrystalline coating

Document Type

Journal Article

Publication Title

Applied Surface Science

Publisher

Elsevier

School

School of Engineering

Comments

Xu, J., Peng, S., Guo, B., Zhao, Y., Fu, T., Jiang, S., ... Lu, H. (2020). Influence of Ag alloying on the antibacterial properties, bio-corrosion resistance and biocompatibility of α-Nb5Si3 nanocrystalline coating. Applied Surface Science, 503, Article 144082. https://doi.org/10.1016/j.apsusc.2019.144082

Abstract

To improve the corrosion resistance and impart the bioactivity and antibacterial functionalities to titanium alloys for biomedical applications, α-(Nb1-xAgx)5Si3 compounds, with three different Ag contents, were deposited on Ti–6Al–4V by double cathode glow discharge method. The new α-(Nb1-xAgx)5Si3 coatings, each about 16 μm in thickness, exhibited a compact uniform structure, composed of equiaxed nanocrystalline grains. Nanoindentation measurements revealed that Ag alloying reduced the hardness (H) and elastic modulus (E) values of the α-(Nb1-xAgx)5Si3 coatings. Compared to Ti–6Al–4V, the α-(Nb1-xAgx)5Si3 coatings exhibited improved corrosion resistance in Ringer's physiological solution, as well as newly added in-vitro bioactivity and antibacterial ability against both E. coli and S. aureus. A MTT assay experiment shows that the two α-(Nb1-xAgx)5Si3(x = 0 and 0.05) coatings were as non-cytotoxic as bare Ti-6Al-4V. However, the MC3T3-E1 osteoblast-like cell viability for the α-(Nb0.9Ag0.1)5Si3 coating was slightly reduced, suggesting that the proliferation of MC3T3-E1 osteoblast-like cell was affected to some degree by excess Ag added to α-Nb5Si3. Overall, the α-(Nb0.95Ag0.05)5Si3 coating provides an attractive combination of good bioactivity, high corrosion resistance and new antibacterial function, and thus demonstrates great potential for applications in orthopedic devices.

DOI

10.1016/j.apsusc.2019.144082

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